Mapping biological process relationships and disease perturbations within a pathway network
نویسندگان
چکیده
منابع مشابه
The Pathway Coexpression Network: Revealing pathway relationships.
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions. However, limited functional references for global pathway relationships exist. Pathways from databases such as KEGG and Reactome provide discrete annotations of biological processes. Their ...
متن کاملComplex-to-Pairwise Mapping of Biological Relationships using a Semantic Network Representation
This study examines representations of protein–protein interactions focusing on the mapping between simple, pairwise annotation and complex, structured annotation. A simple semantic network representation equivalent to the BioInfer predicate formalism is introduced and used to transform the complex annotation of BioInfer into pairwise annotation through hand-written rules. Evaluation shows that...
متن کاملBiological network mapping and source signal deduction
MOTIVATION Many biological networks, including transcriptional regulation, metabolism, and the absorbance spectra of metabolite mixtures, can be represented in a bipartite fashion. Key to understanding these bipartite networks are the network architecture and governing source signals. Such information is often implicitly imbedded in the data. Here we develop a technique, network component mappi...
متن کاملPathway analysis of high-throughput biological data within a Bayesian network framework
MOTIVATION Most current approaches to high-throughput biological data (HTBD) analysis either perform individual gene/protein analysis or, gene/protein set enrichment analysis for a list of biologically relevant molecules. Bayesian Networks (BNs) capture linear and non-linear interactions, handle stochastic events accounting for noise, and focus on local interactions, which can be related to cau...
متن کاملMapping and Analyzing the Co-Authorship Network of Transgenic Researchers with a Network Analysis Approach
Background and Aim: Transgenic species are the ones whose genomes are genetically modified. The transgenic field is one of the areas that has a high importance and position in the world. Therefore, the aim of the present research is to draw and analyze the co-authorship network of researchers in transgenic subject area. Materials and Methods: The type of this research is descriptive and was ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: npj Systems Biology and Applications
سال: 2018
ISSN: 2056-7189
DOI: 10.1038/s41540-018-0055-2